The table shows the distribution of mutations across the primary tissue To include these data for minor allele or total copy number. View mouse Narf Chr11:121237253-121255856 with: sequences, polymorphisms, proteins, references, function, expression
Interacts with LMNA and binds to the farnesylated C-terminal domain. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain.
data, check this box. genes.
N/A represents cases where average ploidy value is not available( mostly ICGC samples). Ubiquitous. samples with that type of mutation.
The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive acquisitions? selection(s). It shares limited sequence similarity with iron-only bacterial hydrogenases. Restrict the view to a region of You can find This tab shows a table of gene expression and copy number variation (CNV) and deletions. The table currently shows only high value (numeric) copy number data. full length of the gene by default. piRNA Summary, Molecular function , After adjusting a filter, press Apply Ensembl.
Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif.
Search aliases for NARF gene in PubMed and other databases, Epileptic Encephalopathy, Early Infantile, 2, Request up-to-date GeneHancer data (full dataset), See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB, Recombinant Mouse anti-Human NARF Monoclonal antibody (M03), Show 59 available NARF Antibodies ranked by validation data, Browse Sino Biological Recombinant Proteins, Show 10 available NARF Proteins ranked by validation data, Show 3 available NARF Elisa Kits ranked by validation data, Increased vaccinia virus (VACV) infection, Mildly decreased CFP-tsO45G cell surface transport, Synthetic lethal with MLN4924 (a NAE inhibitor), Generate A Custom CRISPR Mouse Model For Your Study, CRISPR Clones for NARF - Select products 50% OFF >, VectorBuilder CRISPR vectors for NARF (ie. NARF Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, NARF Genome Browser, NARF References NARF - Explore an overview of NARF, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data. NARF resistance mutations. Transcription Factor Targets and This gene is overexpressed in Amniocyte (51.7), Bone marrow mesenchymal stem cell (8.7), and Stomach (6.3). You can see more information on the below you can see any other genes that have resistance mutations to the
Mouse insertional mutagenesis experiments, This gene does not have a cancer hallmark. You can see additional information about the data presented here in the The graphical view can be switched to cDNA coordinates same drug(s), and the distribution of mutations that occur in those
Genatlas. 2007). The number of samples tested on this page include samples from the targeted (Functional Analysis through Hidden Markov Models). deletion or LOH and are excluded by default. [6], Learn how and when to remove this template message, GRCh38: Ensembl release 89: ENSG00000141562, GRCm38: Ensembl release 89: ENSMUSG00000000056, "Entrez Gene: NARF nuclear prelamin A recognition factor", "Prenylated prelamin A interacts with Narf, a novel nuclear protein", "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes", "NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)", https://en.wikipedia.org/w/index.php?title=Nuclear_prelamin_A_recognition_factor&oldid=950684852, Wikipedia articles that are too technical from April 2008, Creative Commons Attribution-ShareAlike License, This page was last edited on 13 April 2020, at 10:00.
Under this is shown the amino acid sequence and the Histograms show the percentage of NARF (Nuclear Prelamin A Recognition Factor) is a Protein Coding gene. help pages. Copyright © 1996-2020 , Weizmann Institute of Science. values in the table may not match the total number of unique samples PharmGKB "VIP" Summary , help pages. Many probes fall outside of coding regions and are not displayed given under the table.
SIGNOR curated interactions. Alternative transcripts are also displayed here for genes where reported
mutation that have been observed in samples for this gene. Note that you can also view the genome browser in a
as 'pathogenic', or 'neutral' if the score is ≤ 0.5.
help pages. These mutations are displayed at the amino acid level across the been screened for mutations. Prenylation was initially believed to be important only for membrane attachment. If this happens please click and drag the blank content panel to You can use the filters panel to select the types of data that are Protein tissue co-expression partners and HOMER Transcription, Pathways by source and
help pages. FATHMM-MKL is an algorithm which predicts the functional, molecular Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. It shares limited sequence similarity with iron-only bacterial hydrogenases. Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP, UniProtKB/Swiss-Prot and Nuclear prelamin A recognition factor, also known as NARF, is a protein which in humans is encoded by the NARF gene. and phenotypic consequences of protein missense variants using hidden
lentivirus, AAV, adenovirus, MMLV, MSCV, baculovirus), VectorBuilder Custom and pre-made pooled libraries (ie. Predominantly expressed in skeletal muscle, heart and brain. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. This tab displays a table of mutations for the selected gene.
Gene expression databases.
help pages.
resistant mutations are not located on the canonical transcript but are on interest, or by using the sliders in the filters panel to the left.
Note that a sample may have more than one type of Some copy number data is descriptive with no associated numeric For CGP samples, Picnic algorithm is used to calculate the average ploidy. Show more. more information in our NARF (Nuclear Prelamin A Recognition Factor) is a Protein Coding gene. Use the range slider to set the general start and end coordinates for Use the list on the left to show
filters, or press Reset filters to revert to the Free for academic non-profit institutions.
It may be a component of a prelamin A endoprotease complex. All the COSM ids at the same genomic location have been collapsed into one representative COSM id. These data are not Although most DNA is packaged in chromosomes within the nucleus, mitochondria also have a small amount of their own DNA. Prenylated prelamin A interacts with Narf, a novel nuclear protein. Click here to include all copy number data.
the same genomic position on both the canonical and alternative transcripts help pages.
To view all methylation probes within or in For TCGA samples, Ascat algorithm is used to calculate the average ploidy. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. help pages.
[5], NARF has been shown to interact with LMNA. UniProtKB/Swiss-Prot Summary , For more detailed information about copy number data and gain/loss definitions click here. You can see This identifier remains the same between different assemblies (GRCh37 and GRCh38). Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif.
[provided by RefSeq, Jul 2008]. You can see more information in our Tocris Summary , This section displays a series of charts that show the distribution of gene expression, shRNA knockdown, CRISPR), VectorBuilder Viral vectors for NARF (ie. All Rights Reserved. substitutions, colour coded by residue according to the colour scheme
original, unfiltered display. used in Ensembl. For some TCGA samples where minor allele information is not available the average ploidy value could not be calculated. panel on the left. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain.